Optimising the Aerodynamic Performance of Spray Dried mRNA Lipoplexes in Mannitol or Lactose Matrix.
MEGGLE Excipients and the University of Kiel have joined forces to shed light on this interesting topic.
Introduction: Many respiratory pathogens enter the body through the respiratory tract, the lungs and the mucosal immune system are promising targets for therapeutic interventions.
Liquid vaccines face the risk of chemical degradation and physical instability. Solid formulations can secure stability without challenging storage conditions. Since spray drying offers continuous manufacturing with high production capacity, we chose spray drying as production technique.
Objective: Formulation of an Inhalable Dry Powder Platform for mRNA Therapeutics
Authors: Jana Schembera1, Ricarda Leister2, Constanze Müller2, Regina Scherließ1
Many thanks to the authors for this exciting publication.
1 Department of Pharmaceutics and Biopharmaceutics, Kiel University, Germany
2 MEGGLE GmbH & Co. KG, Wasserburg am Inn, Germany
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