Evaluation of the Effect of Fines in Powder Blends in Combination with a Novel Capsule-based Dry Powder Inhaler Device. Introduction: Dry powder inhalers (DPI) depend critically on the interplay between device and formulation. The influence of particle size parameters on the interaction between the active ingredient and excipients is well known, and requires fine tuning...
Magnesium stearate as a force control agent in dry powder inhalation – revisiting the mechanism of action. Introduction: Magnesium stearate (MgSt) is widely used as a lubricant in pharmaceutical formulations and has been extensively investigated in tablet systems, whereas data on its role in dry powder inhalers (DPIs) remain limited. Its lubricating performance is governed...
Nitrite Detection at Trace Levels: Insights from a Lactose Case Study on Ion Chromatography and Sonication Effects Introduction: Nitrite can act as a precursor for the formation of nitrosamines in drug products containing susceptible amines. Most pharmaceutical excipients contain nitrite at ppm or even sub-ppm levels (1), making reliable trace-level quantification essential. This study investigates...
